Structure of PDB 4cnr Chain D

Receptor sequence
>4cnrD (length=258) Species: 9913 (Bos taurus) [Search protein sequence]
HHWGYDKHNGPEHWHKDFPIANGERQSPVDIDTDAVVQDPALKPLALDYG
EATSRRMVNDGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDD
QGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQEPDGLAVVGVFLKVGDA
NPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPL
LESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPEELMLANWRPAQPLKN
RQVRGFPK
3D structure
PDB4cnr Rational Engineering of a Mesohalophilic Carbonic Anhydrase to an Extreme Halotolerant Biocatalyst.
ChainD
Resolution2.29 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H64 H94 H96 E106 H119 T198
Catalytic site (residue number reindexed from 1) H62 H92 H94 E104 H117 T196
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
4.2.1.69: cyanamide hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H94 H96 H119 H92 H94 H117
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0018820 cyanamide hydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015670 carbon dioxide transport
GO:0038166 angiotensin-activated signaling pathway
GO:0044070 regulation of monoatomic anion transport
GO:0051453 regulation of intracellular pH
GO:2001150 positive regulation of dipeptide transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0045177 apical part of cell

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Cellular Component
External links
PDB RCSB:4cnr, PDBe:4cnr, PDBj:4cnr
PDBsum4cnr
PubMed26687908
UniProtP00921|CAH2_BOVIN Carbonic anhydrase 2 (Gene Name=CA2)

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