Structure of PDB 4ch2 Chain D

Receptor sequence

>4ch2D (length=251) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G

3D structure

• PDB: 4ch2 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
• Chain: D
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H363 D419 E522 G523 D524 S525 G526
• Catalytic site (residue number reindexed from 1): H43 D99 E195 G196 D197 S198 G199
• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	E328 G330 M331 P333 W334 F431 D433 H436 P437 C439 Y454 K455 R457 N484 M531 K532 P534 N537 R538 W539	E8 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 P207 N210 R211 W212
BS02	peptide	D	H407 P408 R409 R418 R443 N504 F564 R565 L566 K567 K568	H87 P88 R89 R98 R123 N177 F237 R238 L239 K240 K241
BS03	0G6	D	H363 L416 D519 A520 S525 S546 W547 G548	H43 L96 D192 A193 S198 S219 W220 G221

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:4ch2, PDBe:4ch2, PDBj:4ch2
• PDBsum: 4ch2
• PubMed: 24316004
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)