Structure of PDB 4cfv Chain D

Receptor sequence
>4cfvD (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVE
VGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEI
YPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTINQFLTQYFL
HQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQ
SWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHG
VSLLNPPETLNL
3D structure
PDB4cfv 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D Y347 L348 Y350 Y177 L178 Y180
BS02 MG D M200 Q203 I206 M30 Q33 I36
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:4cfv, PDBe:4cfv, PDBj:4cfv
PDBsum4cfv
PubMed24304238
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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