Structure of PDB 4cff Chain D

Receptor sequence
>4cffD (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKF
FVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCQEPY
VCKPPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGV
MVLSATHRYKKKYVTTLLYKPI
3D structure
PDB4cff Structural Basis of Ampk Regulation by Small Molecule Activators.
ChainD
Resolution3.924 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C1V D S108 V113 S31 V36 PDBbind-CN: -logKd/Ki=6.40,Kd=0.40uM
BindingDB: Kd=487nM,EC50=390nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0007165 signal transduction
GO:0010628 positive regulation of gene expression
GO:0031669 cellular response to nutrient levels
GO:0035878 nail development
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031588 nucleotide-activated protein kinase complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cff, PDBe:4cff, PDBj:4cff
PDBsum4cff
PubMed24352254
UniProtQ9Y478|AAKB1_HUMAN 5'-AMP-activated protein kinase subunit beta-1 (Gene Name=PRKAB1)

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