Structure of PDB 4c5r Chain D

Receptor sequence
>4c5rD (length=636) Species: 29808 (Taxus chinensis) [Search protein sequence]
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRA
RVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLA
GVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKV
PLRGSVSGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPF
KLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGRE
EFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQ
DRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGA
NFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPD
LSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISA
RKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECG
LPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALDTL
VDRLAEFEKRLSDRLENEMTAVRVLYERIQGSKFLPFYRFVREELDTGVM
SARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
3D structure
PDB4c5r Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
ChainD
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y80 G87 L108 N231 Y322 R325 F371 Q459
Catalytic site (residue number reindexed from 1) Y70 G77 L98 N212 Y303 R306 F352 Q440
Enzyme Commision number 4.3.1.24: phenylalanine ammonia-lyase.
5.4.3.10: phenylalanine aminomutase (L-beta-phenylalanine forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BQ7 D Y322 R325 Y303 R306
BS02 BQ7 D Y80 G87 L104 X175 N231 F371 Y70 G77 L94 X158 N212 F352
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016841 ammonia-lyase activity
GO:0016853 isomerase activity
GO:0016869 intramolecular aminotransferase activity
GO:0045548 phenylalanine ammonia-lyase activity
Biological Process
GO:0006558 L-phenylalanine metabolic process
GO:0006559 L-phenylalanine catabolic process
GO:0009698 phenylpropanoid metabolic process
GO:0009800 cinnamic acid biosynthetic process
GO:0009820 alkaloid metabolic process
GO:0009821 alkaloid biosynthetic process
GO:0042617 paclitaxel biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c5r, PDBe:4c5r, PDBj:4c5r
PDBsum4c5r
PubMed24786474
UniProtQ68G84|PAM_TAXCH Phenylalanine aminomutase (L-beta-phenylalanine forming) (Gene Name=pam)

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