Structure of PDB 4c3p Chain D

Receptor sequence
>4c3pD (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGV
EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK
LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIAD
FGWSVHAPLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE
ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEH
PWITANSSKP
3D structure
PDB4c3p Molecular Mechanism of Aurora a Kinase Autophosphorylation and its Allosteric Activation by Tpx2.
ChainD
Resolution2.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N261 D274
Catalytic site (residue number reindexed from 1) N137 D150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R126 Q127 W128 D132 E152 S155 F157 K166 E170 R179 E183 S186 G198 Y199 H201 R2 Q3 W4 D8 E28 S31 F33 K42 E46 R55 E59 S62 G74 Y75 H77
BS02 ACP D L139 G140 V147 K162 Y212 A213 L15 G16 V23 K38 Y88 A89
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:4c3p, PDBe:4c3p, PDBj:4c3p
PDBsum4c3p
PubMed24867643
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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