Structure of PDB 4c2t Chain D

Receptor sequence

>4c2tD (length=645) Species: 1299 (Deinococcus radiodurans) [Search protein sequence]

SAGPDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHY
GVHPGEILAVTFTNKAAAEMRERAGHLVPAGDLWMSTFHSAGVRILRTYG
EHIGLRRGFVIYDDDDQLDIIKEVMGSIPGIGAETQPRVIRGIIDRAKSN
LWTPDDLDRSREPFISGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETV
RLFKEVPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVG
DPDQSIYKFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLI
ENNTERLDKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAW
SEMAILYRTNAQSRVIEESLRRVQIPRIVGGVGFYDRREIRDILAYARLA
LNPADDVALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAAEQN
ILDRGAHKATEFAGLMEAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQ
EGQVRLENLEELVSAAEEWSQDEANVSIADFLDDAALLSSDMRTAEDAVT
LMTLHNAKGLEFPVVFIVGVEQGLLPSKGAIAEGPSGIEEERRLFYVGIT
RAMERLLMTAAQNRMQFGKTNAAEDSAFLEDIEGLFDTVDPYGQP

3D structure

PDB

4c2t Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.

Chain

Resolution

3.997 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K38 T39 D227 E228 Q258 R617
Catalytic site (residue number reindexed from 1)	K35 T36 D223 E224 Q254 R601
Enzyme Commision number	5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	R368 H462 M631 F633	R364 H457 M615 F617	PDBbind-CN: Kd=0.36uM
BS02	dna	D	R142 Y261 F263 R362 N364 A365 R422 G424 I425 S546 H571 N572	R138 Y257 F259 R358 N360 A361 R417 G419 I420 S539 H555 N556	PDBbind-CN: Kd=0.36uM
BS03	MG	D	T39 D227	T36 D223
BS04	ANP	D	A12 G35 S36 G37 K38 T39 R40 Q258 Y290 R291 E577 R617	A9 G32 S33 G34 K35 T36 R37 Q254 Y286 R287 E561 R601

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0016887	ATP hydrolysis activity
GO:0043138	3'-5' DNA helicase activity
GO:0046872	metal ion binding

	Biological Process
GO:0000725	recombinational repair
GO:0032508	DNA duplex unwinding

	Cellular Component
GO:0005829	cytosol
GO:0033202	DNA helicase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4c2t, PDBe:4c2t, PDBj:4c2t
PDBsum	4c2t
PubMed	24143224
UniProt	Q9RTI9

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