Structure of PDB 4bny Chain D

Receptor sequence
>4bnyD (length=244) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
FQSMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAE
TLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGIVRMKD
DEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTN
YAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREAL
LGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS
3D structure
PDB4bny Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa
ChainD
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G16 S141 Y154 K158
Catalytic site (residue number reindexed from 1) G19 S138 Y151 K155
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 36I D F107 V110 N111 L114 A156 G160 F104 V107 N108 L111 A153 G157 MOAD: ic50=0.08uM
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4bny, PDBe:4bny, PDBj:4bny
PDBsum4bny
PubMed24015914
UniProtO54438|FABG_PSEAE 3-oxoacyl-[acyl-carrier-protein] reductase FabG (Gene Name=fabG)

[Back to BioLiP]