Structure of PDB 4beb Chain D

Receptor sequence
>4bebD (length=833) Species: 562 (Escherichia coli) [Search protein sequence]
NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLA
NVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFI
FDDERLENIYLIDKKNLMRNKVQIIQQFRYDVTILVNGLPLVQIELKKRG
VAIREAFNQINSLFKYLQLFVISNGTDTRYFANTTKRDENSFDFTMNWAK
SDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQIAATE
RILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATELDFID
KVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDNKIIVT
TIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKFKRYYQ
FGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFKVDYND
VRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQKTHRT
FPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFS
FAEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSNGFQNYYRD
LAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLMQAFSRTN
RIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKSYTEYMEGF
TDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLFGEYLRAEN
ILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAELQTIRLPAD
RKIQDYRSAYNDIRDWQRRTDWDDVVFEVDLLK
3D structure
PDB4beb Functional Coupling of Duplex Translocation to DNA Cleavage in a Type I Restriction Enzyme.
ChainD
Resolution2.989 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.3: type I site-specific deoxyribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D D408 E409 D377 E378
BS02 ATP D M227 V271 R273 Q276 G312 K313 T314 T661 D664 R688 R691 M196 V240 R242 Q245 G281 K282 T283 T621 D624 R648 R651
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0005524 ATP binding
GO:0009035 type I site-specific deoxyribonuclease activity
Biological Process
GO:0006304 DNA modification
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:4beb, PDBe:4beb, PDBj:4beb
PDBsum4beb
PubMed26039067
UniProtP10486|T1R1_ECOLX Type I restriction enzyme EcoR124I/EcoR124II endonuclease subunit (Gene Name=hsdR)

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