Structure of PDB 4av1 Chain D

Receptor sequence
>4av1D (length=95) Species: 9606 (Homo sapiens) [Search protein sequence]
KTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRW
YHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGV
3D structure
PDB4av1 The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D K119 S120 T124 R138 D145 K148 L151 I154 K12 S13 T17 R31 D38 K41 L44 I47
BS02 ZN D C125 C128 H159 C162 C18 C21 H52 C55
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4av1, PDBe:4av1, PDBj:4av1
PDBsum4av1
PubMed22683995
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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