Structure of PDB 4a59 Chain D

Receptor sequence
>4a59D (length=595) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
DADTEKRINVGKKHLQTLRNLETRCHDSLQALVVIDAGSSSTRTNVFLAK
TRSCPNKGRSIDPDSIQLIGAGKRFAGLRVVLEEWLDTYAGKDWESRPVD
ARLLFQYVPQMHEGAKKLMQLLEEDTVAILDSQLNEKQKVQVKALGIPVM
LCSTAGVRDFHEWYRDALFVLLRHLINNPSPAHGYKFFTNPFWTRPITGA
EEGLFAFITLNHLSRRLGEDPARCMIDEYGVKQCRNDLAGVVEVGGASAQ
IVFPLQEGTVLPSSVRAVNLQRERLLPERYPSADVVSVSFMQLGMASSAG
LFLKELCSNDEFLQGGICSNPCLFKGFQQSCSAGEVEVRPDGSASVNEDV
RKNRLKPLATYCSVNNPEISFKVTNEMQCRENSIDPTKPLAERMKIENCS
IIKGTGNFDKCVSQVESILVAPKLPLPANIEAASSGFESVDQVFRFASST
APMIVTGGGMLAAINTLKDHRLLRSDFSGDVEELAEAAREFCSSEVIIRT
DGPVIQLPNARGEQKLNSLNFDLCKTMALTVSLLRHMAAGENQPSFIKWE
KSIAGPDGKPLADLGWQVGVILHHVLFTEEWGRNAYEAGYSHNLE
3D structure
PDB4a59 Structural Insight Into the Activation Mechanism of Toxoplasma Gondii Nucleoside Triphosphate Diphosphohydrolases by Disulfide Reduction.
ChainD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 AMP D G280 M329 G492 G493 A496 L553 G246 M295 G458 G459 A462 L519
BS02 AMP D H195 N399 N400 H161 N365 N366
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
Cellular Component
GO:0005576 extracellular region
GO:0020003 symbiont-containing vacuole

View graph for
Molecular Function

View graph for
Cellular Component
External links
PDB RCSB:4a59, PDBe:4a59, PDBj:4a59
PDBsum4a59
PubMed22130673
UniProtQ27893|NTP1_TOXGO Nucleoside-triphosphatase 1 (Gene Name=NTP3)

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