Structure of PDB 3w67 Chain D

Receptor sequence
>3w67D (length=251) Species: 10090 (Mus musculus) [Search protein sequence]
QPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLDLAWRLMKNYY
KWRAECPELSADLRPRSILGLLKAGYHGVLRSRDSTGSRVLIYRIAYWDP
KVFTAYDVFRVSLITSELIVQEVETQRNGVKAIFDLEGWQVSHAFQITPS
VAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHL
HGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIMKSEDYLSSIS
E
3D structure
PDB3w67 Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
ChainD
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VIV D S136 S140 F158 V182 L183 F187 I194 S112 S116 F134 V158 L159 F163 I170
BS02 3PT D L183 T184 K190 V191 R192 I218 R221 L159 T160 K166 V167 R168 I194 R197
Gene Ontology
Molecular Function
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008289 lipid binding
GO:0008431 vitamin E binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0120013 lipid transfer activity
Biological Process
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0009636 response to toxic substance
GO:0042360 vitamin E metabolic process
GO:0051180 vitamin transport
GO:0090212 negative regulation of establishment of blood-brain barrier
GO:0120009 intermembrane lipid transfer
GO:1900223 positive regulation of amyloid-beta clearance
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w67, PDBe:3w67, PDBj:3w67
PDBsum3w67
PubMed23599266
UniProtQ8BWP5|TTPA_MOUSE Alpha-tocopherol transfer protein (Gene Name=Ttpa)

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