Structure of PDB 3uk6 Chain D

Receptor sequence
>3uk6D (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
GAHSHIRGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVL
IAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFR
RSIGVRIVSLHEIDVINSRTQGFFSGDTGEIKSEVREQINAKVAEWIIPG
VLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPH
GIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIG
LETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYM
3D structure
PDB3uk6 Large-Scale Conformational Flexibility Determines the Properties of AAA+ TIP49 ATPases.
ChainD
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP D A24 H25 H27 M46 V47 G80 T81 G82 K83 T84 A85 Y362 I370 A2 H3 H5 M22 V23 G56 T57 G58 K59 T60 A61 Y218 I226
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3uk6, PDBe:3uk6, PDBj:3uk6
PDBsum3uk6
PubMed22748767
UniProtQ9Y230|RUVB2_HUMAN RuvB-like 2 (Gene Name=RUVBL2)

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