Structure of PDB 3udl Chain D

Receptor sequence
>3udlD (length=555) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
SMSYTWTGALITPCAAEESKLPLSNSLLRHHNMVYATTSRSAGLRQKKVT
FDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGY
GAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPAR
LIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTW
KSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTE
RLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKL
QDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEY
DLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSW
LGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLD
LPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVR
ARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGG
DIYHS
3D structure
PDB3udl Quinolones as HCV NS5B polymerase inhibitors.
ChainD
Resolution2.174 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KLI D R422 M423 H475 S476 Y477 P479 I482 N483 V485 A486 W528 R414 M415 H467 S468 Y469 P471 I474 N475 V477 A478 W520
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3udl, PDBe:3udl, PDBj:3udl
PDBsum3udl
PubMed21145235
UniProtP26663|POLG_HCVBK Genome polyprotein

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