Structure of PDB 3twv Chain D

Receptor sequence
>3twvD (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR
VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA
DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD
IQDLLR
3D structure
PDB3twv Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainD
Resolution2.301 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D N537 V539 E543 E573 N49 V51 E55 E85
BS02 peptide D R525 S527 F532 G535 Y536 L560 Y569 H571 D589 W591 F593 E598 K602 K604 R37 S39 F44 G47 Y48 L72 Y81 H83 D101 W103 F105 E110 K114 K116
External links
PDB RCSB:3twv, PDBe:3twv, PDBj:3twv
PDBsum3twv
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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