Structure of PDB 3twt Chain D

Receptor sequence
>3twtD (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA
GYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV
VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD
GDTDIQDLLR
3D structure
PDB3twt Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainD
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D N537 V539 E543 E573 N53 V55 E59 E89
BS02 peptide D R525 F532 G535 Y536 L560 N565 S568 Y569 H571 D589 W591 F593 E598 K604 R41 F48 G51 Y52 L76 N81 S84 Y85 H87 D105 W107 F109 E114 K120
External links
PDB RCSB:3twt, PDBe:3twt, PDBj:3twt
PDBsum3twt
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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