Structure of PDB 3tuz Chain D

Receptor sequence
>3tuzD (length=343) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRC
VNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVF
GNVALPLELDNTPKDEVKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVA
IARALASNPKVLLCDQATSALDPATTRSILELLKDINRRLGLTILLITHE
MDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIP
EDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQ
MDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
3D structure
PDB3tuz Inward facing conformations of the MetNI methionine ABC transporter: Implications for the mechanism of transinhibition.
ChainD
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.4.2.11: ABC-type methionine transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MSE D F273 V278 A280 L282 L283 Q300 M301 F273 V278 A280 L282 L283 Q300 M301
BS02 ADP D F11 G41 G43 K44 S45 T46 F11 G41 G43 K44 S45 T46
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015191 L-methionine transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0033232 ABC-type D-methionine transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
Biological Process
GO:0006865 amino acid transport
GO:0048473 D-methionine transmembrane transport
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903692 methionine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009276 Gram-negative-bacterium-type cell wall
GO:0016020 membrane
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990197 methionine-importing ABC transporter complex

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Cellular Component
External links
PDB RCSB:3tuz, PDBe:3tuz, PDBj:3tuz
PDBsum3tuz
PubMed22095702
UniProtP30750|METN_ECOLI Methionine import ATP-binding protein MetN (Gene Name=metN)

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