Structure of PDB 3tht Chain D

Receptor sequence
>3thtD (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
TLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMP
PNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKE
LRPQALPPGLMVVEEIISSEEEKMLLESVDWTHRRVKHFGYLPDICESFL
EKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEI
VMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESL
KSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKENLY
FQ
3D structure
PDB3tht Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
ChainD
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.229: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H242 C343 C349 H184 C285 C291
BS02 MN D H238 D240 H292 H180 D182 H234
BS03 AKG D N227 Y229 M260 H292 R328 S330 T332 R334 N169 Y171 M202 H234 R270 S272 T274 R276
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0070988 demethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3tht, PDBe:3tht, PDBj:3tht
PDBsum3tht
PubMed22065580
UniProtQ96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 (Gene Name=ALKBH8)

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