Structure of PDB 3t1i Chain D

Receptor sequence
>3t1iD (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
DDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILL
GGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFP
NLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDI
SPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLF
VIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYIS
QPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVL
ANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVR
LRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFR
3D structure
PDB3t1i Crystal structure of human mre11: understanding tumorigenic mutations
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D D20 H22 D60 H247 D13 H15 D53 H233
BS02 MN D D60 N128 H217 H245 D53 N114 H203 H231
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0030870 Mre11 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t1i, PDBe:3t1i, PDBj:3t1i
PDBsum3t1i
PubMed22078559
UniProtP49959|MRE11_HUMAN Double-strand break repair protein MRE11 (Gene Name=MRE11)

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