Structure of PDB 3suf Chain D

Receptor sequence
>3sufD (length=183) [Search protein sequence]
GSVVIVGRINLSGDTAYAQQTRGEGCQETSQTGRDKNGEVQIVSTATQTF
LATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPRSLTP
CTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCP
AGHAVGIFRAAVCTRGVAKAVAFIPVESLETTM
3D structure
PDB3suf The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
ChainD
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H64 D88 G141 S143
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SUE D Q1041 F1043 Y1056 H1057 G1058 V1078 D1081 L1135 G1137 S1139 F1154 R1155 A1156 A1157 C1159 Q48 F50 Y63 H64 G65 V85 D88 L139 G141 S143 F158 R159 A160 A161 C163 MOAD: Ki=27.8nM
BS02 ZN D C1145 H1149 C149 H153
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3suf, PDBe:3suf, PDBj:3suf
PDBsum3suf
PubMed22910833
UniProtA8DG50

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