Structure of PDB 3ssn Chain D

Receptor sequence
>3ssnD (length=393) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
TEFDEATVQDVVRLAGGHDSELRELTQKYDPAMISRLLVAEILSRCPPPS
NDTPVLVELAIVHGSERFRHFLRVVRDSPIRPVGADEGFVGMLVEYELTE
LLRELFGVTHERPAGVRGTKLFPYLTDDEEAVEQIGTYLLAAQQGTEAVL
AGCGSRKPDLSELSSRYFTPKFGFLHWFTPHYDRHFRDYRNQQVRVLEIG
VGGYKHPEWGGGSLRMWKSFFPRGQIYGLDIMDKSHVDELRIRTIQGDQN
DAEFLDRIARRYGPFDIVIDDGSHINAHVRTSFAALFPHVRPGGLYVIED
MWTAYWPGFGGQADPQECSGTSLGLLKSLIDAIQHQELPSDPNRSPGYVD
RNIVGLHVYHNVAFVEKGRNDEGGIPTWIPRDFESLVQASSGG
3D structure
PDB3ssn A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
ChainD
Resolution2.392 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.238: mycinamicin VI 2''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MVI D I383 L390 S394 I379 L386 S390
BS02 MG D D275 D304 D271 D300
BS03 SAH D T173 K175 E202 G204 V205 G206 Y208 S217 D234 I235 Q253 D275 G276 S277 H282 T169 K171 E198 G200 V201 G202 Y204 S213 D230 I231 Q249 D271 G272 S273 H278
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0046872 metal ion binding
GO:0102302 mycinamicin VI 2''-O-methyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation
GO:0051289 protein homotetramerization

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Molecular Function
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Biological Process
External links
PDB RCSB:3ssn, PDBe:3ssn, PDBj:3ssn
PDBsum3ssn
PubMed21884704
UniProtQ83WF2|MYCE_MICGR Mycinamicin VI 2''-O-methyltransferase (Gene Name=mycE)

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