Structure of PDB 3ss4 Chain D

Receptor sequence
>3ss4D (length=387) Species: 10090 (Mus musculus) [Search protein sequence]
LEDLLFYTIQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTVM
LDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGG
KVADFSPDLWGVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLG
TEYVHRYVGKEPSGFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDY
VMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDM
VGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTL
SLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDK
MGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRR
3D structure
PDB3ss4 Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
ChainD
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S291 K294 Y419 Y471 V489
Catalytic site (residue number reindexed from 1) S135 K138 Y257 Y309 V327
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 D S291 N340 R392 S135 N178 R230
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3ss4, PDBe:3ss4, PDBj:3ss4
PDBsum3ss4
PubMed22228304
UniProtD3Z7P3|GLSK_MOUSE Glutaminase kidney isoform, mitochondrial (Gene Name=Gls)

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