Structure of PDB 3spl Chain D

Receptor sequence
>3splD (length=200) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
SFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHLT
HVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALANY
IKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPTS
NLPTRGTLTSLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSVSM
3D structure
PDB3spl Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA
ChainD
Resolution2.101 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D F34 R209 H210 F211 T212 F2 R177 H178 F179 T180
BS02 dna D F34 F65 K67 S142 A164 H165 F194 F2 F33 K35 S110 A132 H133 F162
BS03 ZN D C200 C203 H217 E221 C168 C171 H185 E189
BS04 AMP D L38 Y41 D63 M64 F65 H138 P141 S142 M143 H147 H149 L6 Y9 D31 M32 F33 H106 P109 S110 M111 H115 H117
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:3spl, PDBe:3spl, PDBj:3spl
PDBsum3spl
PubMed21984208
UniProtO74859|APTX_SCHPO Aprataxin-like protein (Gene Name=hnt3)

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