Structure of PDB 3si7 Chain D

Receptor sequence
>3si7D (length=261) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKSHLCLVGNPVLKNINLNIEKGEMLAITG
STGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENIIG
VSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLA
RAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEH
LRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRS
SILTETLRRFS
3D structure
PDB3si7 Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences
ChainD
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D W401 V440 T460 G461 S462 G463 K464 T465 S466 W12 V32 T52 G53 S54 G55 K56 T57 S58
BS02 MG D T465 Q493 T57 Q85
BS03 MG D G451 A596 G43 A187
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3si7, PDBe:3si7, PDBj:3si7
PDBsum3si7
PubMed22265409
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

[Back to BioLiP]