Structure of PDB 3roj Chain D

Receptor sequence

>3rojD (length=346) Species: 1148 (Synechocystis sp. PCC 6803)

SVDSTLGLEIIEVVEQAAIASAKWMGKGEKNTADQVAVEAMRERMNKIHM
RGRIVIGEGERDDAPMLYIGEEVGICTREDAKSFCNPDELVEIDIAVDPC
EGTNLVAYGQNGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGHVDIDK
SATENLKILSDCLNRSIEELVVVVMDRPRHKELIQEIRNAGARVRLISDG
DVSAAISCAFSGTNIHALMGIGAAPEGVISAAAMRCLGGHFQGQLIYDPE
VVKTGLIGESREGNLERLASMGIKNPDQVYNCEELACGETVLFAACGITP
GTLMEGVRFFHGGVRTQSLVISSQSSTARFVDTVHMKESPKVIQLH

3D structure

• PDB: 3roj New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling
• Chain: D
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.11: fructose-bisphosphatase.
  3.1.3.37: sedoheptulose-bisphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	D	R307 F309 R314 V341 I342 Q343 H345	R308 F310 R315 V342 I343 Q344 H346
BS02	AMP	D	R164 G211 N213 H215	R165 G212 N214 H216
BS03	MG	D	D97 E100 E225	D98 E101 E226
BS04	MG	D	D33 E57 P98 C99	D34 E58 P99 C100

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
• GO:0046872 metal ion binding
• GO:0050278 sedoheptulose-bisphosphatase activity

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0006094 gluconeogenesis
• GO:0019253 reductive pentose-phosphate cycle
• GO:0030388 fructose 1,6-bisphosphate metabolic process

External links

• PDB: RCSB:3roj, PDBe:3roj, PDBj:3roj
• PDBsum: 3roj
• UniProt: P73922|FBSB_SYNY3 D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase (Gene Name=slr2094)