Structure of PDB 3rjm Chain D

Receptor sequence
>3rjmD (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
KMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVA
DMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPP
3D structure
PDB3rjm Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
ChainD
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.55: caspase-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D A228 A229 M230 R231 N232 T233 W238 G272 Y273 F279 A21 A22 M23 R24 N25 T26 W31 G65 Y66 F72
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3rjm, PDBe:3rjm, PDBj:3rjm
PDBsum3rjm
PubMed21903398
UniProtP42575|CASP2_HUMAN Caspase-2 (Gene Name=CASP2)

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