Structure of PDB 3r2j Chain D

Receptor sequence
>3r2jD (length=199) Species: 5671 (Leishmania infantum) [Search protein sequence]
TLCVTVSSTTDVLIIADMQVDFLAPGGSLHVKGGEALLDGINAVSSQLPF
RYQVATQDWHPENHCSFVTHGGPWPPHCVQGSAGAQLHAGLHTQRINAVI
RKGVTQQADSYSAFVEDNGVSTGLAGLLHSIGARRVFVCGVAYDFCVFFT
AMDARKNGFSVVLLEDLTAAVDDAAWSARTAELKDAGVVLLKSSALVAE
3D structure
PDB3r2j The Leishmania nicotinamidase is essential for NAD(+) production and parasite proliferation.
ChainD
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 D73 H75 S81 H92 K117 D124 A157 C161
Catalytic site (residue number reindexed from 1) D17 D58 H60 S66 H77 K102 D109 A142 C146
Enzyme Commision number 3.5.1.19: nicotinamidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D73 H75 H92 D58 H60 H77
BS02 NIO D D32 D73 W89 H92 A157 F160 C161 D17 D58 W74 H77 A142 F145 C146
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0019363 pyridine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3r2j, PDBe:3r2j, PDBj:3r2j
PDBsum3r2j
PubMed21819459
UniProtA4HRG8

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