Structure of PDB 3qz1 Chain D

Receptor sequence
>3qz1D (length=434) Species: 9913 (Bos taurus) [Search protein sequence]
HLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI
EEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSAL
LLSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNK
EDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIEN
RDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVQLLEGHVHMSVVDLFIGG
TETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPVTYKDRARLPLLNAT
IAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVW
EQPHEFRPDRFLEPGANPSALAFGCGARVCLGESLARLELFVVLARLLQA
FTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQ
3D structure
PDB3qz1 Crystal Structure of Bovine Steroid of 21-hydroxylase (P450c21)
ChainD
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T294 F420 C427
Catalytic site (residue number reindexed from 1) T253 F373 C380
Enzyme Commision number 1.14.14.16: steroid 21-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D R92 S109 G291 T294 T298 L352 V358 A361 H364 A419 F420 R425 C427 L428 G429 A433 R64 S81 G250 T253 T257 L305 V311 A314 H317 A372 F373 R378 C380 L381 G382 A386
BS02 3QZ D S109 L196 R232 T294 S81 L165 R201 T253
BS03 3QZ D L64 Q206 L360 A361 L36 Q175 L313 A314
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004509 steroid 21-monooxygenase activity
GO:0005496 steroid binding
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0103069 17-hydroxyprogesterone 21-hydroxylase activity
GO:0106309 progesterone 21-hydroxylase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0008202 steroid metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qz1, PDBe:3qz1, PDBj:3qz1
PDBsum3qz1
PubMed
UniProtP00191|CP21A_BOVIN Steroid 21-hydroxylase (Gene Name=CYP21)

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