Structure of PDB 3qs1 Chain D

Receptor sequence
>3qs1D (length=326) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
GDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGC
KTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKF
IEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQA
VFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFG
NLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNP
KLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILG
DPFMRKYFTVFDYDNHTVGFALAKKK
3D structure
PDB3qs1 Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.
ChainD
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 N37 W39 Y75 D215 T218
Catalytic site (residue number reindexed from 1) D32 S35 N37 W39 Y75 D212 T215
Enzyme Commision number 3.4.23.38: plasmepsin I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 006 D D32 G34 Y75 V76 S77 I130 Y189 D215 T218 S219 I287 L291 I300 D32 G34 Y75 V76 S77 I131 Y190 D212 T215 S216 I288 L292 I298 BindingDB: IC50=280nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3qs1, PDBe:3qs1, PDBj:3qs1
PDBsum3qs1
PubMed21521654
UniProtP39898|PLM1_PLAFX Plasmepsin I (Gene Name=PMI)

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