Structure of PDB 3plf Chain D

Receptor sequence
>3plfD (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
GTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTI
LSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPR
RNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKT
IVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLF
QPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCT
RLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPD
L
3D structure
PDB3plf An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
ChainD
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D S80 P81 Y274 R294 S296 C297 T298 L315 Q316 T317 I318 S32 P33 Y226 R246 S248 C249 T250 L267 Q268 T269 I270
BS02 CA D D229 T231 N233 Y235 E240 D181 T183 N185 Y187 E192
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3plf, PDBe:3plf, PDBj:3plf
PDBsum3plf
PubMed21163258
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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