Structure of PDB 3pe3 Chain D

Receptor sequence
>3pe3D (length=701) Species: 9606 (Homo sapiens) [Search protein sequence]
SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCALNMPVIPMNTIAEAVI
EMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGL
PEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQ
QYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVL
WAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDL
EYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI
K
3D structure
PDB3pe3 Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
ChainD
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP D Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 Q512 K515 L539 V568 A569 K571 H574 H593 T594 T595 D598 BindingDB: IC50=1800nM
External links
PDB RCSB:3pe3, PDBe:3pe3, PDBj:3pe3
PDBsum3pe3
PubMed21240259
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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