Structure of PDB 3os9 Chain D

Receptor sequence
>3os9D (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVP
GFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQM
VEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTLEEKDHIHRVL
DKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYVPS
YDLLLEML
3D structure
PDB3os9 Coupling of receptor conformation and ligand orientation determine graded activity.
ChainD
Resolution2.303 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 KN1 D A350 D351 L384 G521 A35 D36 L69 G192 BindingDB: IC50=1300nM
BS02 KN1 D L346 E353 L391 F404 L31 E38 L76 F89 BindingDB: IC50=1300nM
External links
PDB RCSB:3os9, PDBe:3os9, PDBj:3os9
PDBsum3os9
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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