Structure of PDB 3olr Chain D

Receptor sequence
>3olrD (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
MASMDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTT
VAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPK
AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPG
EMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHD
VPSSIDPILELIWDVRCYQEDDSVPICIHSSAGCGRTGVICAIDYTWMLL
KDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
3D structure
PDB3olr Structure basis of LYP substrate specificity revealed by reverse alanine screening and crystallography
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D195 S227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) D198 S230 R236 T237 Q277
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R59 Y60 K61 D62 M134 S227 S228 A229 C231 G232 R233 Q274 R62 Y63 K64 D65 M137 S230 S231 A232 C234 G235 R236 Q277
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3olr, PDBe:3olr, PDBj:3olr
PDBsum3olr
PubMed
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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