Structure of PDB 3oad Chain D

Receptor sequence
>3oadD (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
SLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDG
CLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISF
HLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI
RKFYTEFDRRNNRIGFALARH
3D structure
PDB3oad Design and optimization of new piperidines as renin inhibitors.
ChainD
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D226 A229
Catalytic site (residue number reindexed from 1) D56 A59
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LPO D D226 G228 D56 G58 BindingDB: IC50=0.12nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3oad, PDBe:3oad, PDBj:3oad
PDBsum3oad
PubMed20843686
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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