Structure of PDB 3n96 Chain D

Receptor sequence
>3n96D (length=468) Species: 9606,83333 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGWGPP
PYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLE
NGTWASKINYSQCEPILD
3D structure
PDB3n96 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
ChainD
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Q-321 Q46 I47 F68 N69 G70 V71 Y73 K92 I93 Y95 P100 Q49 Q411 I412 F433 N434 G435 V436 Y438 K457 I458 Y460 P465
BS02 GLC D D-356 K-355 E-259 D14 K15 E111
BS03 GLC D D-305 R-304 E-217 P-216 Y-215 W-30 D65 R66 E153 P154 Y155 W340
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:3n96, PDBe:3n96, PDBj:3n96
PDBsum3n96
PubMed
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)

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