Structure of PDB 3n95 Chain D

Receptor sequence
>3n95D (length=463) Species: 9606,83333 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGYSYC
NTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWA
SKINYSQCEPILD
3D structure
PDB3n95 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
ChainD
Resolution2.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D P-322 Q-321 A-318 S-297 I47 F68 N69 Y73 K92 I93 Y95 P48 Q49 A52 S73 I407 F428 N429 Y433 K452 I453 Y455
BS02 GLC D D-356 K-355 E-259 D14 K15 E111
BS03 GLC D W-308 D-305 R-304 E-217 P-216 Y-215 W-30 W62 D65 R66 E153 P154 Y155 W340
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:3n95, PDBe:3n95, PDBj:3n95
PDBsum3n95
PubMed
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)

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