Structure of PDB 3mgv Chain D

Receptor sequence

>3mgvD (length=322) Species: 10678 (Punavirus P1) [Search protein sequence]

SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPE
DVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRR
IRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYN
TLLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTK
LVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATH
RLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVN
IVMNYIRNLDSETGAMVRLLED

3D structure

PDB

3mgv Requirements for catalysis in the Cre recombinase active site.

Chain

Resolution

2.29 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	M44 S47 R50 R81 A84 K86 T87 Q90 A131 K132 R159 K201 R241 V242 K244 L256 S257 R259 A260 R282 Y324 R326	M25 S28 R31 R62 A65 K67 T68 Q71 A112 K113 R140 K182 R222 V223 K225 L237 S238 R240 A241 R263 Y305 R307
BS02	dna	D	R118 K122 R173 K201 T202 W315 T316 N317 I320	R99 K103 R154 K182 T183 W296 T297 N298 I301
BS03	dna	D	F37 S38 H40 T41 Q90 M97 R100 R101 R106 R118 R121 R173 I174 A175 K201 R243 K244 N245 R259 E262 K276 R282 Y283 S287 G288 H289	F18 S19 H21 T22 Q71 M78 R81 R82 R87 R99 R102 R154 I155 A156 K182 R224 K225 N226 R240 E243 K257 R263 Y264 S268 G269 H270
BS04	VO4	D	R173 H289 R292 W315 Y324	R154 H270 R273 W296 Y305

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3mgv, PDBe:3mgv, PDBj:3mgv
PDBsum	3mgv
PubMed	20462863
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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