Structure of PDB 3lzb Chain D

Receptor sequence
>3lzbD (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKAN
KEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHK
DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDF
GLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE
ISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMA
RDPQRYLVIQG
3D structure
PDB3lzb Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R681 W707 Q767 R3 W29 Q85
BS02 ITI D L694 V702 A719 K721 M742 C751 L753 T766 L768 M769 G772 L820 T830 D831 F832 L834 L16 V24 A41 K43 M60 C69 L71 T84 L86 M87 G90 L138 T148 D149 F150 L152 BindingDB: Ki=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lzb, PDBe:3lzb, PDBj:3lzb
PDBsum3lzb
PubMed20346655
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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