Structure of PDB 3lpp Chain D

Receptor sequence
>3lppD (length=853) Species: 9606 (Homo sapiens) [Search protein sequence]
LNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNV
QDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPN
NRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTS
IGPLVYSDQYLQISARLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQL
PGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRV
TGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLD
VVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLH
DHGQKYVIILDPAISIGRRYATYERGNTQHVWINESDGSTPIIGEVWPGL
TVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCN
VNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATE
QAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLE
FSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQD
PAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEF
YEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKR
PWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALG
ENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGT
TLAFQTVKILGLTDSVTEVRVAEHSNFTYDASNQVLLIADLKLNLGRNFS
VQW
3D structure
PDB3lpp Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.
ChainD
Resolution2.15 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.10: oligo-1,6-glucosidase.
3.2.1.48: sucrose alpha-glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KTL D D231 W327 D355 W435 W470 D472 M473 K509 R555 D571 F604 D198 W294 D322 W397 W432 D434 M435 K471 R517 D533 F566 MOAD: Ki=0.6uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lpp, PDBe:3lpp, PDBj:3lpp
PDBsum3lpp
PubMed20356844
UniProtP14410|SUIS_HUMAN Sucrase-isomaltase, intestinal (Gene Name=SI)

[Back to BioLiP]