Structure of PDB 3ldw Chain D

Receptor sequence
>3ldwD (length=352) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
FRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGI
LVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYC
WYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATLK
TIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVIH
KTAYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYLDIFG
DSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKV
IDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFT
GV
3D structure
PDB3ldw Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
ChainD
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K45 A81 D86 D90 R95 D158 K201 F239 D243 D244
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOL D D126 R135 Q195 K243 T244 D287 K301 D86 R95 Q155 K201 T202 D243 K257 MOAD: Ki=10.7nM
BS02 IPE D K81 R84 Q119 R136 F283 D287 K45 R48 Q79 R96 F239 D243
BS03 MG D D126 D130 D86 D90
BS04 MG D D126 D130 D86 D90
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ldw, PDBe:3ldw, PDBj:3ldw
PDBsum3ldw
PubMed21084289
UniProtA5K4U6

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