Structure of PDB 3lap Chain D

Receptor sequence
>3lapD (length=154) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NRAGRQARIVAILSSAQVRSQNELAALLAAEGIEVTQATLSRDLEELGAV
KLRGADGGTGIYVVPEDGSPVRGVSGGTDRMARLLGELLVSTDDSGNLAV
LRTPPGAAHYLASAIDRAALPQVVGTIAGDDTILVVAREPTTGAQLAGMF
ENLR
3D structure
PDB3lap crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.
ChainD
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D S36 Q37 Q53 A54 S57 K67 Y78 S20 Q21 Q37 A38 S41 K51 Y62
BS02 dna D R18 R21 T52 T55 R58 R2 R5 T36 T39 R42
BS03 GGB D D132 T142 D116 T126
BS04 GGB D G145 D146 D147 T148 G129 D130 D131 T132
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0034618 arginine binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006525 arginine metabolic process
GO:0006526 L-arginine biosynthetic process
GO:0051259 protein complex oligomerization
GO:1900079 regulation of arginine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3lap, PDBe:3lap, PDBj:3lap
PDBsum3lap
PubMed20382162
UniProtP9WPY9|ARGR_MYCTU Arginine repressor (Gene Name=argR)

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