Structure of PDB 3l4d Chain D

Receptor sequence
>3l4dD (length=445) Species: 5671 (Leishmania infantum) [Search protein sequence]
KGKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRIT
VVGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLN
FLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINT
ACQCLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYR
CRDARAELQDILSEIIIAREKEEANTSDLLAGLLGAVYRDGTRMSQHEVC
GMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFPAQLNY
DNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIAC
SPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVHKCIGEKFGLLQ
VKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIKKK
3D structure
PDB3l4d Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14{alpha}-Demethylase (CYP51) from Leishmania infantum.
ChainD
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L355 C422
Catalytic site (residue number reindexed from 1) L324 C391
Enzyme Commision number 1.14.13.70: Transferred entry: 1.14.14.154.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D Y102 Y115 R123 L133 A290 T294 L355 L358 R360 G414 F415 G416 H420 C422 I423 G424 Y75 Y88 R96 L106 A259 T263 L324 L327 R329 G383 F384 G385 H389 C391 I392 G393
BS02 TPF D A286 F289 A290 T294 L355 M459 A255 F258 A259 T263 L324 M428
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3l4d, PDBe:3l4d, PDBj:3l4d
PDBsum3l4d
PubMed21632531
UniProtA2TEF2

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