Structure of PDB 3kt8 Chain D

Receptor sequence
>3kt8D (length=410) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ELKSTDVKEQVVTPWDVEGGVDEQGRAQNIDYDKLIKQFGTKPVNEETLK
RFKQVTGREPHHFLRKGLFFSERDFTKILDLYEQGKPFFLYTGRGPSSDS
MHLGHMIPFVFTKWLQEVFDVPLVIELTDDEKFLFKHKLTINDVKNFARE
NAKDIIAVGFDPKNTFIFSDLQYMGGAFYETVVRVSRQITGSTAKAVFGF
NDSDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDPYFRV
CRDVADKLKYSKPALLHSRFFPALQGSTTKMSASDDTTAIFMTDTPKQIQ
KKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLSFFKDDDVFLKECYDK
YKSGELLSGEMKKLCIETLQEFVKAFQERRAQVDEETLDKFMVPHKLVWG
EKERLVAPKP
3D structure
PDB3kt8 Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LTN D Y106 T107 G108 R109 E141 E146 Q230 C255 Q259 F263 Y91 T92 G93 R94 E126 E131 Q215 C240 Q244 F248
BS02 SO4 D F148 T155 I156 F133 T140 I141
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3kt8, PDBe:3kt8, PDBj:3kt8
PDBsum3kt8
PubMed20123733
UniProtQ12109|SYWC_YEAST Tryptophan--tRNA ligase, cytoplasmic (Gene Name=WRS1)

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