Structure of PDB 3kmg Chain D

Receptor sequence
>3kmgD (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKY
GVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEF
AVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQ
EIYKDL
3D structure
PDB3kmg Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Q294 K301 L311 V315 K319 P467 L468 E471 Q74 K81 L91 V95 K99 P247 L248 E251
BS02 538 D F282 G284 C285 Q286 R288 S289 H323 I326 Y327 L330 I341 S342 F363 H449 Y473 F62 G64 C65 Q66 R68 S69 H103 I106 Y107 L110 I121 S122 F143 H229 Y253 BindingDB: EC50=0.8nM,IC50=8nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kmg, PDBe:3kmg, PDBj:3kmg
PDBsum3kmg
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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