Structure of PDB 3k09 Chain D

Receptor sequence

>3k09D (length=485) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

EHQAIAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNG
IIEFDEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPE
GQEVVGGFDLSALIERINYAIQKYRARRVSIDSVTSVFQQYDASSVVRRE
LFRLVARLKQIGATTVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEG
ERRRRTLEILKLRGTSHMKGEYPFTITDHGINIFPLGAMRLTQRSSNVRV
SSGVVRLDEMCGGGFFKDSIILATGATGTGKTLLVSRFVENACANKERAI
LFAYEESRAQLLRNAYSWGMDFEEMERQNLLKIVCAYPESAGLEDHLQII
KSEINDFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGLFT
NTSDQFMGAHSITDSHIDTITDTIILLQYVEIRGEMSRAINVFKMRGSWH
DKAIREFMISDKGPDIKDSFRNFERIISGSPTRIT

3D structure

PDB

3k09 Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	D	K457 M458 R459 S461 W462 H463	K444 M445 R446 S448 W449 H450
BS02	ATP	D	K224 L225 R226 T228 H230	K211 L212 R213 T215 H217
BS03	MG	D	T53 D145	T40 D132
BS04	ATP	D	T290 G291 T292 G293 K294 T295 L296 W331 R451 I472	T277 G278 T279 G280 K281 T282 L283 W318 R438 I459
BS05	ATP	D	G49 T50 G51 K52 T53 L54 S89 F90 I239	G36 T37 G38 K39 T40 L41 S76 F77 I226

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3k09, PDBe:3k09, PDBj:3k09
PDBsum	3k09
PubMed	19956664
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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