Structure of PDB 3ig6 Chain D

Receptor sequence
>3ig6D (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHSVTYVCGGSLISPCWVISATHCFIDYPK
KEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI
RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQ
LKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLV
CSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB3ig6 Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)
ChainD
Resolution1.83 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D94 Q192 G193 D194 S195 G196
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D N26 W29 P49 A112 Q113 P114 R116 Q119 T120 C122 R206 M207 N11 W14 P35 A108 Q109 P110 R112 Q115 T116 C118 R206 M207
BS02 438 D I60 K92 Y94 S95 A96 I46 K82 Y84 S85 A86 MOAD: ic50=0.025uM
BindingDB: IC50=25nM
BS03 438 D K143 D189 S190 C191 Q192 W215 G216 R217 G218 K139 D189 S190 C191 Q192 W215 G216 R217 G218 MOAD: ic50=0.025uM
BindingDB: IC50=25nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ig6, PDBe:3ig6, PDBj:3ig6
PDBsum3ig6
PubMed19703768
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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