Structure of PDB 3hrz Chain D

Receptor sequence
>3hrzD (length=693) Species: 9606 (Homo sapiens) [Search protein sequence]
SCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTL
KTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGY
TLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLED
SVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFL
SSLTETKRKIVLDPSGSMNIYLVLDGSGSIGASDFTGAKKCLVNLIEKVA
SYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKS
GTNTKKALQAVYSMMSWPVPPEGWNRTRHVIILMTDGLHNMGGDPITVID
EIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVF
KVKDMENLEDVFYQMIDESQSLSLCGMVWEHTDYHKQPWQAKISVIRPSC
MGAVVSEYFVLTAAHCFTHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKE
AGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQ
QQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGY
DKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGV
ISWGVVDVCKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFLA
3D structure
PDB3hrz Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H501 D551 G672 S674 G675
Catalytic site (residue number reindexed from 1) H465 D510 G631 S633 G634
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S253 S255 T328 S227 S229 T302
Gene Ontology
Molecular Function
GO:0001848 complement binding
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hrz, PDBe:3hrz, PDBj:3hrz
PDBsum3hrz
PubMed19574954
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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