Structure of PDB 3hgw Chain D

Receptor sequence
>3hgwD (length=97) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
KTPEDCTGLADIREAIDRIDLDIVQALGRRMDYVKAASRFKASEAAIPAP
ERVAAMLPERARWAEENGLDAPFVEGLFAQIIHWYTAEQIKYWRQTR
3D structure
PDB3hgw Structure-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme
ChainD
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.2.99.21: isochorismate lyase.
5.4.99.5: chorismate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D E15 D18 E14 D17
Gene Ontology
Molecular Function
GO:0004106 chorismate mutase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0016853 isomerase activity
GO:0043904 isochorismate pyruvate lyase activity
Biological Process
GO:0009697 salicylic acid biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0042864 pyochelin biosynthetic process
GO:0046417 chorismate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3hgw, PDBe:3hgw, PDBj:3hgw
PDBsum3hgw
PubMed19432488
UniProtQ51507|PCHB_PSEAE Isochorismate pyruvate lyase (Gene Name=pchB)

[Back to BioLiP]