Structure of PDB 3h64 Chain D

Receptor sequence
>3h64D (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
EDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTL
KETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVE
VILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELF
SEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPM
CDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKA
EGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPH
PNVKPMAYA
3D structure
PDB3h64 Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D D271 N303 H352 H427 D90 N122 H171 H246
BS02 MN D D242 H244 D271 D61 H63 D90
BS03 ENL D D242 H244 R275 H304 R400 H427 F446 Y451 D61 H63 R94 H123 R219 H246 F265 Y270
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:3h64, PDBe:3h64, PDBj:3h64
PDBsum3h64
PubMed19601647
UniProtP53041|PPP5_HUMAN Serine/threonine-protein phosphatase 5 (Gene Name=PPP5C)

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