Structure of PDB 3h52 Chain D

Receptor sequence
>3h52D (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLEMLAEIITNQINGNIKKLLFHQ
3D structure
PDB3h52 Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations
ChainD
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 486 D L563 N564 G567 Q570 M601 M639 Y735 C736 L753 L34 N35 G38 Q41 M72 M110 Y206 C207 L215 BindingDB: IC50=1.1nM,Ki=1.2nM,EC50=872nM,Kd=15nM
External links
PDB RCSB:3h52, PDBe:3h52, PDBj:3h52
PDBsum3h52
PubMed19913032
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]